This report reviews the international literature that explores mental health and well-being issues for staff and students in higher education, and looks at approaches at institutional and national levels that can support the mental health and well-being of university communities. It presents a review of institutional approaches, with a focus on the EU’s higher education sector, highlighting models that have been successfully applied within diverse higher education contexts. Lastly, it provides a set of recommendations for improving mental health and well-being of students and staff at HEIs across the EU through the implementation of holistic, whole-institution approaches.